Robert Ingham, PhD

Dept. of Medical Microbiology & Immunology
University of Alberta
Faculty of Medicine & Dentistry
6-142H Katz Group Centre
T6G 2E1 Edmonton, AB
Canada

Ph : (780) 248-1980
Fx : (780) 492-7521
Em: ringham@ualberta.ca

 

 

Positions:

• Assistant Professor, Dept. of Medical Microbiology & Immunology

Research:

Signal transduction pathways control aspects of lymphocyte biology including development, activation, survival, and migration. The importance of these pathways is underscored by the fact that when these pathways are dysregulated, immunodeficiency, autoimmunity, or cancer can result. My laboratory studies the molecular mechanisms of lymphocyte signalling, and we are particularly interested in the role protein-protein interactions and post-translational modifications play in regulating these events. Specific interests of the laboratory include: elucidating how the Epstein-Barr virus protein, LMP2A, co-opts lymphocyte signalling pathways, the function of protein ubiquitylation in lymphocyte signalling, and understanding how dysregulated signalling contributes to the pathogenesis of B and T cell lymphomas. We use a variety of molecular biology and biochemical techniques as well as cell-based assays in our studies.

People:

• Jason Lee (Graduate Student)
• Joel Pearson (Graduate Student)

 

Publications:

Click here for most recent publications

 

Selected Publications:

1) Pearson JD, Lee JK, Bacani JT, Lai R, and Ingham RJ. NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma. Int J Clin Exp Pathol. 4(2):124-33. 2011

2) Wang  P., Wu F., Zhang, J., McMullen T., Young L.C., Ingham R.J., Li L., and R. Lai. Serine phosphorylation of NPM-ALK contributes to its oncogenic potential. Carcinogenesis. 32(2): 146-53. 2011

3) Hegazy S.A., Wang P, Anand M, Ingham R.J., Gelebart P, Lai R. The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions. Journal of Biological Chemistry. 285(26): 19813-20. 2010.

4) Alford S.C., Pearson J.D., Carette A., Ingham R.J., and P.L. Howard. alpha-Sarcin catalytic activity is not required for cytotoxicity. BMC Biochemistry. 10(9). 2009.

5) Lim C.S., Seet B.T., Ingham R.J., Gish G., Matskova L., Winberg G., Ernberg I., and T. Pawson. The K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Recruits the Endocytic Regulator Intersectin 2 through a Selective SH3 Domain Interaction. Biochemistry. 46(35): 9874-9885. 2007.

6) Matskova L.V., Helmstetter C., Ingham R.J., Gish G., Lindholm C.K., Ernberg I., Pawson T., and G. Winberg. The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane protein. Oncogene. 26(34): 4908-4917. 2007.

7) Bruck S., Huber T.B., Ingham R.J., Kim K., Niederstrasser H., Allen P.M., Pawson T., Cooper J.A., and A. Shaw. Identification of a Novel Inhibitory Actin-capping Protein Binding Motif in CD2-associated Protein. Journal of Biological Chemistry. 281(28): 19196-19203. 2006.

8) Ingham R.J., Raaijmakers J., Lim C.S.H., Mbamalu G., Gish G., Chen F., Matskova L., Ernberg I., Winberg G., and T. Pawson. The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor. Journal of Biological Chemistry. 280(40): 34133-34142. 2005.

9) Ingham R.J., Colwill K., Howard C., Dettwiler S., Lim C.S.H., Yu J., Hersi K., Raaijmakers J., Gish G., Mbamalu G., Taylor L., Yeung B., Vassilovski G., Amin M., Chen F., Matskova L., Winberg G., Ernberg I., Linding R., O'Donnell P., Starostine A., Keller W., Metalnikov P., Stark C., and T. Pawson. WW Domains Provide a Platform for the Assembly of Multi-Protein Complexes. Molecular and CellularBiology. 25(16): 7092-7106. 2005.