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Staff & Students

Postdoctoral Fellows

huDr. Nancy Hu

E-mail: qhu@ualberta.ca

Phone: (780) 492-6958

Supervisor: Dr. Troy Baldwin

Alma Mater: University of Alberta

Academic Interests:

My research examines the molecular mechanisms of thymocyte negative selection, particularly the function and role of the proteins Bim and Nur77 in this process.

Non-Academic Interests:

Biking, running, dancing, music and volunteering.


fillerperson

Dr. Chad Irwin

E-mail: crirwin@ualberta.ca

Phone: (780) 492-2106

Supervisor: Dr. David Evans

 

 

 

 


santer

Dr. Deanna Santer

Position: Postdoctoral Fellow

E-mail: deanna.santer@ualberta.ca

Phone: (780) 492-1216

Supervisor: Dr. Michael Houghton

Alma Mater: University of Washington (PhD)

 

Academic Interests:

My research will look into the mechanism of B cell lymphoproiferative disease associated with Hepatitis C virus infection.

Non-Academic Interests:

Most sports & travelling

Awards:

  • CIHR postdoctoral fellowship (2012-2015)
  • Alberta Innovates Health Solutions Postdoctoral Fellowship (2011-2014)
  • Exceptional Student Award (Cyto 2010 Conference)
  • Ray Owen Young Investigator Award (Midwinter Conference of Immunologists 2010)
  • NSERC PGS-D/M (2005-2009)

Publications:

  1. Egli A, Levin A, Santer DM, Joyce M, O’Shea D, Thomas B, Lisboa LF, Barakat K, Bhat R, Fischer K, Houghton M, Tyrrell DL, Kumar D, Humar A. Immunomodulatory function of interleukin-28B during primary infection with Cytomegalovirus. J Infect Dis Mar 2014, doi: 10.1093/infdis/jiu144
  2. Egli A, Santer DM, Barakat K, Zand M, Levin A, Vollmer M, Weisser M, Khanna N, Kumar D, Tyrrell DL, Houghton M, Battegay M, O’Shea D. Vaccine adjuvants - understanding molecular mechanisms to improve vaccines. Swiss Medical Weekly 'in press’ (accepted Feb 3, 2014)
  3. Landi A, Weismuller TJ, Lankisch TO, Santer DM, Tyrrell DL, Manns MP, Houghton M. 2013. Differential Serum Levels of Eosinophilic Eotaxins in Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, and Autoimmune Hepatitis. J Interferon Cytokine Res. Oct 29. [Epub ahead of print]
  4. Santer DM, Ma MM, Hockman D, Landi A, Tyrrell DL, Houghton M. 2013. Enhanced activation of memory, but not naïve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis. PLoS One. 8(6): e68308.
  5. Wiedeman AE, Santer DM, Yan W, Miescher S, Käsermann F, Elkon KB. 2013. Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists. Arthritis Rheum. 65(10): 2713-2723.
  6. Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M. 2013. A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. PLoS One. 8(3): e59776.
  7. Elkon KB and Santer DM. 2012. Complement, interferon and lupus. Curr Opin Immunol. 24(6):665-670.
  8. Santer DM, Wiedeman AE, Teal TH, Ghosh P, Elkon KB. 2012. Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes. J Immunol. Jan 15;188(2):902-15.
  9. Steffen I, Tyrrell DL, Stein E, Montalvo L, Lee TH, Zhou Y, Lu K, Switzer WM, Tang S, Jia H, Hockman D, Santer DM, Logan M, Landi A, Law J, Houghton M, Simmons G. 2011. No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome. PLoS One. 6(11):e27870.
  10. Santer DM, Hall BE, George TC, Liu CL, Utz PJ, Arkwright PD, Elkon KB. 2010. C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. J Immunol. 185(8):4738-4749.
  11. Chino T, Santer DM, Giordano D, Chen C, Li C, Chen C-H, Darveau RP, Clark EA. 2009. Effects of oral commensal and pathogenic bacteria on human monocyte derived dendritic cells. Oral Microbiol Immunol. Apr;24(2):96-103.
  12. Santer DM, Yoshio T, Minota S, Möller T, Elkon KB. 2009. Potent Induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus. J Immunol. 182(2):1192-1201.
  13. Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, Arnett FC, Elkon KB. 2008. Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis. Arthritis Rheum. 58(7):2163-2173.
  14. Schoenborn JR, Dorschner MO, Sekimata M, Santer DM, Shnyreva M, Fitzpatrick DR, Stamatoyannopoulos JA, Wilson CB. 2007. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol. 8(7):732-742.

 

M. Sarhan

Dr. Mohammed Sarhan

Position: Postdoctoral Fellow

E-mail: msarhan@ualberta.ca

Phone: (780) 492-1216

Supervisor: Dr. Michael Houghton

Alma Mater: Graduated from the Faculty of Medicine, Cairo University

Research interest:
My research and clinical area of interest is in the field of viral hepatitis and immune response. Specially HCV lymphotropism and mechanisms of HCV infection and entry. We have interestingly been able to uncover certain T cell specific molecules that might be potentially considered in future HCV therapies.

Non-academic interests:

Reading and painting and teaching.

Awards:

  • National CIHR Training Program for Hep C Award for 2013
  • CASL Student Research Prize. Canadian Digestive Diseases Week (CDDW) Canadian Association for Study of the Liver (CASL). Montreal, Quebec, Canada, 2012.
  • CASL Student Research Prize, Canadian Digestive Diseases Week (CDDW) Canadian Association for Study of the Liver (CASL). Vancouver, British Colombia, Canada, 2011.
  • Fellow of the School of Graduate Studies and Distinction Award. Memorial University of Newfoundland, St. John’s, NL, Canada. 2010
  • Young Investigator Award, Canadian Digestive Diseases Week (CDDW) Canadian Association for Study of the Liver (CASL). Toronto, Ontario, Canada, 2010.
  • Best Student Research Award, American Association for the Study of Liver Diseases (AASLD). Boston, Massachusetts, USA, 2009.
  • Best Basic Research Award, National Canadian Research Training Program in Hepatitis C. Toronto, Ontario, Canada, 2008.
  • Graduate Student Fellowship Award for PhD degree, National Canadian Research Training Program in Hepatitis C. Canada, 2008.
  • Graduate Student Fellowship Award for Professional Certificate of Nosocomial Infection Control. American University of Cairo, Egypt, 2005.
  • Graduate Student Fellowship Award for M.Sc. degree, Microbiology and Immunology department. National Liver Institute, Menofia University, Egypt, 2000.
  • Undergraduate Award for Bachelor of Medicine and Surgery. Faculty of Medicine, Cairo University, Egypt, 1990.

    Peer Reviewed Journal Publications and Theses:
  1. Sarhan M.A., Chen AY, Michalak TI. Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus. PLoS One. 2013 Apr 23;8(4):e62159. doi: 10.1371/journal.pone.0062159. Print 2013.
  2. Sarhan M. A., T. N. Q. Pham, A. Y. Chen, and T. I. Michalak (2012). Hepatitis C Virus Infection of Human T Lymphocytes is Mediated by CD5. J Virol. 2012 Apr;86(7):3723-35.
  3. Sarhan M. A., Chen AY, Russell RS, Michalak TI (2012). Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes. J Gen Virol. 2012 Nov;93(Pt 11):2399-407
  4. Eissa N. A., Bakr A., Kura B., Taha H.A. and Sarhan M.A. Helicobacter pylori CagA and VacA antibodies as a pathogenic markers for peptic ulcer disease in patients with HCV and HBV-related cirrhosis. Egyptian Journal of Medical Microbiology, 2003 July; 12(3): 517-28.
  5. Sarhan M. A., Thesis for Master of Clinical and Chemical Pathology. Update of Prion Diseases in Human. Kasr El-Aini School of Medicine, Cairo University, Cairo, Egypt. 2003-2005.
  6. Sarhan M. A., Thesis for Master of Medical Bacteriology: Helicobacter pylori infection in HCV and HBV positive patients with cirrhosis. Faculty of Medicine, Menofia University, Menofia, Egypt. 2000-2003.